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The novel coronavirus pneumonia epidemic has spread to 200 countries and regions according to the data released by WHO. The number of confirmed cases has exceeded 1 million cases worldwide, and more than 50 thousand cases have died. Previous studies have suggested that cats may be potentially susceptible to sars-cov-2. It is not clear whether sars-cov-2 can directly infect testis or male reproductive tract and spread sexually from male.
On April 4, 2020, Liu Yun and other teams of Nanjing Medical University published a research paper entitled "detection of 2019 Novell coronavirus in men and experimental biology vision of covid-19 patients" on medrxiv online, a prepress platform, which included 12 rehabilitation patients and 1 patient who died of covid-19 from January 31 to March 14, 2020. In order to detect the presence of sexual transmission in men, real-time PCR (RT-PCR) was used to detect sars-cov-2 in semen or testicular biopsy samples. The results showed that the age range of 12 patients was 22-38 years old. All patients did not have severe covid-19 pneumonia.
As of March 14, 2020, 10 patients have been discharged from hospital, and the remaining 2 have entered the rehabilitation stage. Sars-cov-2 RNA was negative in all recovered semen samples. Another patient, 67 years old, died on March 10, 2020, and tissue samples from testicular biopsies were negative for viral RNA. In summary, sars-cov-2 was not found in semen or testicular biopsies. The results of this study suggest that there is no evidence of sexual transmission of sars-cov-2 in men. However, due to the small sample size of the study, more research is needed to support the research results.
Due to the rapid increase of new cases, the coronavirus disease (covid-19) in 2019 soon attracted global attention. The novel coronavirus infection is thought to be transmitted from animal, and the pathogen is identified as SARS-CoV-2. By January 2020, it is suspected that the first infected patients were infected with the virus through human to human transmission. Since January 2020, the virus has spread rapidly to most parts of China and other countries. As of April 4, 2020, there are more than 1 million confirmed cases and more than 50000 deaths in the world. These figures are updated daily and are expected to increase further.
Previous studies have confirmed that the new coronavirus (sars-cov-2) enters the host cell through ACE2 and TMPRSS2 as receptors. Based on the analysis of scrna SEQ, ACE2 was widely expressed in spermatogonia, Leydig cells and Sertoli cells of testis. TMPRSS2 mainly exists in spermatogonia and spermatids.
It is not clear whether sars-cov-2 can directly infect testis or male reproductive tract and spread sexually from male. The descriptive study included 12 convalescent patients and one patient who died of covid-19 between January 31 and March 14, 2020. In order to detect the presence of sexual transmission in men, real-time PCR (RT-PCR) was used to detect sars-cov-2 in semen or testicular biopsy samples. The results showed that the age range of 12 patients was 22-38 years old. All patients did not have severe covid-19 pneumonia.
As of March 14, 2020, 10 patients have been discharged from hospital, and the remaining 2 have entered the rehabilitation stage. Sars-cov-2 RNA was negative in all recovered semen samples. Another patient, 67 years old, died on March 10, 2020, and tissue samples from testicular biopsies were negative for viral RNA.
In summary, sars-cov-2 was not found in semen or testicular biopsies. The results of this study suggest that there is no evidence of sexual transmission of sars-cov-2 in men.
Reference message:
https://www.medrxiv.org/content/10.1101/2020.03.31.20042333v1
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