Click the "blue words" button above to subscribe. Although the research on bioelectronics has been in-depth in recent years, and significant progress has been made, the self-adhesive bioelectrons that can adhere to human tissues and achieve better signal detection without using external auxiliary tools are still a challenge. So far, there are only a few reports of self-adhesive Bioelectronics, and they are largely limited to signal collection on the skin, but no other applications, such as tactile sensors and implanted neural interface electrodes, have been reported. Due to the complex application environment and some strict requirements, including biocompatibility, biological stability, and wet adhesion ability in the humoral environment, it is still a difficult task to introduce self-adhesion into the currently available bioelectronic materials. The strategy of imitating mussel provides a new idea for self-adhesive bioelectrode, from skin adhesive patch to implantable integrated bioelectronics.
Professor Lu Xiong of Southwest Jiao Tong University has been engaged in the design and preparation of imitated mussel adhesive hydrogels for a long time, and has made a series of research results. The mechanism of redox dynamic equilibrium of phenolquinones based on the imitation mussel strategy has been innovatively proposed. The hydrogels (ACS Nano 2017, 11, 2561, Nat. Comm., 2019, 101487; Adv. Funct. Mater. 2019) have been developed for a long time. 1907678）。 Based on the idea of material genetic engineering, based on the guidance of quantum mechanics, we designed the reaction system elaborately, and used high throughput preparation and characterization technology to conduct multi factor and multi level screening. We developed a series of multifunctional biomedical new hydrogels.
In view of the innovative work in the field of self adhesive hydrogel, recently, Professor Lu Xiong of Southwest Jiao Tong University invited the invitation to "Mussel-inspired hydrogels for self-adhesive bioelectronics" (DOI:10.1002/adfm.201909954) in the Adv. Funct. Mater. journal. In this paper, the latest development of self-adhesive hydrogel bioelectronics based on mussel inspired in recent years is systematically summarized. Based on the mechanism proposed by the team, the mechanism of hydroquinone redox mechanism controlled by space confinement and electron transfer is given to bioelectronic self adhesion of hydrogels and other functions, such as super mechanical properties, self repair, transparency, antibacterial properties, high temperature resistance and frost resistance. , underwater adhesion, etc. Finally, the paper focuses on the challenges and future directions of the development of multifunctional hydrogels for self adhered bioelectronics. Xie chaoming, associate professor of Southwest Jiaotong University, is the first author of this paper. Lu Xiong, Professor of Southwest Jiaotong University, and Ding Yonghui, research assistant professor of Northwest University, are co authors.
Figure 1. The mussel like strategy provides a new way for wearable / implanted bioelectronics to change from external assisted fixation to convenient and reliable self adhesion.
Fig. 2. adhesion mechanism of mussel and long term self adherent hydrogel design strategy
In this paper, the properties of self adhered hydrogels based on bioelectronics in five aspects are discussed in detail.
(1) imitated mussel chemistry is used to develop self adherent hydrogel bioelectrons with super mechanical strength, breaking through the traditional tough and tough hydrogel lacking surface adhesion and cell affinity, and can not be used for tissue repair and regeneration problems.
Fig. 3. self adhered hydrogel bioelectronics with super mechanical properties
(2) imitated mussel chemistry is used to develop self adhesive hydrogel bioelectronics with self-healing ability, which realizes self repairing of damaged structure and performance of self adhered hydrogel, and ensures its long-term and stable use.
Fig. 4. self adhesive hydrogel bioelectronics with its own repair capability
(3) imitated mussel chemistry is used to develop transparent mussel self adhesive hydrogel Bioelectronics, which solves the problem of poor biocompatibility of nano filled conductive hydrogel and ionic conductive hydrogel, and can not be used for visualization of bioelectronic applications.
Fig. 5. self adherent hydrogel bioelectronics with transparency
(4) imitated mussel chemistry is used to develop antibacterial, self adhesive hydrogel Bioelectronics, which reduces the risk of implantable self adhered hydrogels.
Fig. 6. self adhesive hydrogel bioelectronics with antibacterial properties
(5) imitated mussel chemistry is used for the development of simulated mussel self adhesive hydrogel bioelectronics for extreme environment, which extends its application environment, such as high temperature, extreme cold and underwater environment, as well as human body surface sweat wetting environment and human body implant fluid erosion environment.
Fig. 7. self adhered hydrogel bioelectronics for extreme environments
Fig. 8. self adhesive hydrogel for humid environment
Finally, the challenges and future directions of the development of multifunctional hydrogels for self adhered bioelectronics are highlighted.
1) research and development of multifunctional self-adhesive hydrogel bioelectronics;
2) to develop stable implantable self-adhesive hydrogel bioelectronics combined with complex internal environment.
3) develop self adhesive hydrogel surface bioelectronics for various extreme environments.
4) The application of extended mussel adhesion mechanism in the design of self-adhesive bioelectronics.
Paper link:
https://onlinelibrary.wiley.com/doi/10.1002/adfm.201909954
Relevant progress
Professor Lu Xiong of Southwest Jiao Tong University has made breakthrough in the imitation of mussel guided electromagnetic fluid based hydrogel.
Southwest Jiao Tong University professor Lu Xiong Chem. Mater.: catechol metal ion autocatalytic system for the preparation of conductive super hydrogel
The latest progress of Lu Xiong's team's super adhesive hydrogel at Southwest Jiao Tong University: plant inspired dynamic catechol chemical hydrogel
The research team of Professor Lu Xiong of Southwest Jiao Tong University has obtained the latest research results in the field of adhesive and enhanced antibacterial hydrogel.
Professor Lu Hsiung, research group of Southwest Jiaotong University: conductive super hydrogel based on bioactive molecular template to control conductive polymer nanorods in situ.
Southwest Jiao Tong University professor Lu Xiong research group: imitation mussel hybrid polysaccharide self adherent hydrogel
Professor Lu Xiong of Southwest Jiaotong University has developed a mussel like stimulus responsive conductive microcapsule
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