Article reprinted from "China Pharmaceutical University (ID: CPU 1936)"
In front of the epidemic, scientific research is not limited. In order to defeat the new coronavirus as soon as possible, experts and scholars in various fields at home and abroad are racing against the clock to study the relevant professional knowledge of coronavirus and contribute to the fight against the epidemic. However, it is undeniable that the current web platform about coronavirus miscellaneous page information may reduce the efficiency of researchers to find new coronavirus professional information and related research literature. Recently, the editor learned that sun Qingrong, a doctoral student majoring in pharmacology of 2018 in school of basic medicine and clinical pharmacy of our university, led his team "CPU virus group" to successfully develop a coronavirus resource bank (CRB for short, website: http://cov.cpu.edu.cn/). Homepage of coronavirus resource database platform (CRB)
This is a resource database platform specially developed for researchers of coronavirus. As introduced on the homepage of the website, the database platform comprehensively integrates all the relevant literature, virus related data and virus research related analysis tools at home and abroad, aiming to enable scholars to easily and quickly find the relevant research literature of coronavirus (including new coronavirus), accurately grasp and deeply understand the origin and research of coronavirus History, research process, research hotspot, etc., so as to promote researchers in various fields to conduct all-round and multi angle in-depth research and Discussion on coronavirus, promote the interdisciplinary integration of pharmacy, chemistry, biology and other disciplines, and help researchers at home and abroad to break new coronavirus as soon as possible, so as to benefit human health.
Time as the axis runs through China and foreign countries
Retrospection of coronavirus related literature spanning more than 50 years
According to the editor, although it is only 32 days since the establishment and improvement of CRB, the number of literature resources integrated in CRB should not be underestimated. As of March 22, 9556 English research documents, 3052 Chinese research documents, 25 English data resource platforms, 6 Chinese data resource platforms and 18 main analysis tools related to virology were collected in the database. Domestic research plate of coronavirus international research plate of coronavirus
Although the massive coronavirus data information is comprehensive and detailed, it also brings the difficulty of classification. In order to keep researchers at home and abroad from being confused in the vast database, Dr. Sun Qingrong's team specially displayed the database page in Chinese and English respectively, which was clearly divided into two parts, namely "domestic coronavirus research" and "international coronavirus research". Under these two plates, there are many sub columns, which respectively cover all relevant research reports and review papers, all data resource systems (platforms) of coronavirus, analysis tools related to virology, patent information related to coronavirus, etc. The latest update of Chinese research literature the latest update of English research literature
It is worth mentioning that the research reports and review papers in the database are arranged and launched with the time axis as the core. They are traced from the earliest 1965 to 2020, with a time span of 55 years. Thus, researchers can consult relevant literature and materials based on the time sequence to quickly understand the research status and process of coronavirus in each year, so as to trace the roots Tracing back to the source, in-depth exploration. The establishment of a resource database is not a process of blind integration of data. Developers need to filter the data, and the coronavirus resource database (CRB) is no exception. According to the editor, Dr. Sun Qingrong's team has not simply integrated the vast amount of literature research materials from 1960s to now, but focused on a specific goal, eliminated some critical and strategic articles, and only retained the relevant contents such as academic research, academic review, case analysis, data platform, analysis tools, etc., which can better concentrate and effectively Academic resources, both accurate coverage and comprehensive science, truly serve the research work of coronavirus.
No matter how kind you are, you can go ahead
"If you always think about scientific research in your mind, it will always surprise you"
Why develop and create a coronavirus resource database (CRB)? When talking about the original intention of database development, Dr. Sun Qingrong said frankly that this development inspiration mainly comes from his tutor. It is understood that sun Qingrong is a Ph.D. student majoring in pharmacology of China Pharmaceutical University, who is a member of German Academy of Sciences and President of China Pharmaceutical University. Dr. Sun Qingrong was dispatched to the center of physiology and pathology, School of basic medicine, Zhejiang University to study gene mutation in colorectal cancer metastasis. His main research direction was big data of tumor bioinformatics. In the teaching process, Professor laimaode often encouraged his students: "for a scientific researcher, always think about scientific research in his mind, because you always think about it, it will always surprise you." In novel coronavirus pneumonia, Professor Maud encouraged students to do more research on new crown virus from the perspective of big data, including multiple sequence alignment, evolutionary analysis and ACE2 protein analysis. Sun Qing Rong
Because of the cross field research, sun Qingrong admitted that in the research process, he found that his early research and analysis strategies for viruses could not be as skilled as in the research of tumors. Therefore, with the encouragement of his tutor, Professor laimaode, he initiated the idea of developing and creating an integrated coronavirus resource and related research database to facilitate researchers outside the virology major to engage in related research. Therefore, in the situation of severe epidemic situation and isolation at home, Dr. Sun Qingrong and 11 like-minded undergraduates from pharmacy, clinical pharmacy, Chinese pharmacy, biopharmaceutical and other specialties of China Pharmaceutical University quickly set up a "CPU virus group" team. Together, everyone looked up the literature, sorted out the data, built the website, and started the establishment of the coronavirus resource database Work...
Dr. Sun Qingrong, a member of the CPU virus team, said frankly that the establishment of the coronavirus resource database (CRB) is not an easy process. There have been various difficulties in the construction of the basic environment of the database server, data integration, information display and other links. "The basic environment construction of database server needs relevant professionals to realize, and the integration of data needs manual retrieval and screening, with a huge workload. There are also some problems with library resources, which also need the help of professionals. In addition, they need to work at home during the epidemic. Due to the difference of family network of team members, the optimal network time is also different, so it will be a little difficult to coordinate and unify. " "CPU virus group" team members consult literature at home
In the face of many obstacles, Dr. Sun Qingrong did not flinch. He effectively led the team in data collection and integration through a reasonable planning of the data sector. For domestic resources, due to the relatively small number, they use manual retrieval as the main way to check China HowNet and Wanfang database one by one; for foreign resources, they use the combination of API and manual retrieval to achieve data integration and warehousing. In order to make people more convenient to see the information, they analyzed the data transfer interface of other data platforms, in order to establish a fast channel for the platform to the original database. Many small partners of the team have overcome various practical difficulties, realized the coordination and unification of different places, and completed the daily work tasks efficiently. In addition, Dr. Sun Qingrong especially thanked professor laimaode and the teachers of the school's book and Information Center for their careful guidance and strong support. "Without the help of teachers, we can't complete team building, basic environment building and database testing."
Practice the original heart, never stop
"Although we can't reach the front line of anti epidemic, we hope to help break down the virus as soon as possible"
When the editor asked whether integrating these huge data was boring, Dr. Sun Qingrong smiled: "because I like it, I'm happy, not boring." It is understood that China Pharmaceutical University is the place where sun Qingrong's dream begins and where his original intention lies. With his pursuit and unremitting efforts in pharmaceutical research, sun Qingrong is now specializing in his most interested professional direction. "I'm really lucky, because the Pharmaceutical University has provided superior scientific research conditions, my tutor has given me careful guidance and warm help, and the college and counselor have provided meticulous care and care, which makes me pursue my dream all the way and never give up." Sun Qingrong, a remote access database server at home, said his experience in developing the database had inspired him deeply in drug research. It not only has a deep understanding of the development history of coronavirus, but also has opened up a field of vision in the process of subject integration, and has harvested its own new ideas in the field of big data research of tumor bioinformatics. "Understanding the mechanism of the virus is the beginning of drug development. Only through a large number of studies on the mechanism of virus, can we accelerate the development of drug screening vaccine and benefit the cause of human health. " Sun Qingrong exclaimed that although he could not reach the front line of anti epidemic, as a pharmaceutical research worker, he hoped to make use of his professional director to do his part in epidemic prevention and control, and he hoped to transform the thinking in other fields into the field of Virology, so as to promote the scientific research workers in all fields to carry out all-round and multi angle deep research and Discussion on coronavirus and help the country Researchers at home and abroad will break through the new coronavirus as soon as possible, and hope that people all over the world can get through the difficulties and overcome the epidemic as soon as possible. It is reported that in the next stage, Dr. Sun Qingrong's team will continue to update the database platform resources, and add more data analysis and data resources of coronavirus related drugs.
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Source: China Pharmaceutical University
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