In Lingnan area, which advocates dietotherapy and health preservation,
Tangerine peel is the standard food for Cantonese.
They especially like to put a few pieces of tangerine peel in the soup,
Besides seasoning,
The most important thing is to keep healthy.
New meeting orange peel
It can be said that Cantonese love tangerine peel so much,
It is inseparable from its excellent medical and health care value.
Recently, another study shows that,
Polymethoxyflavone (pmfe) in tangerine peel can alleviate the metabolic syndrome induced by high fat diet. (1)
What is it? Come and have a look!
In the international journal Science advanced, it successfully published "citrus polymethoxyflavone improves metabolic syndrome by regulating intestinal flora and amino acid metabolism"
It was jointly carried out by xinbaotang and China University of Pharmaceutical Sciences, and the project "citrus polyoxyflavone improves metabolic syndrome by regulating intestinal flora and amino acid metabolism" presided over by researcher Liu Ehu found that the polyoxyflavone extract (pmfe) from citrus peel is a potential prebiotic for the treatment of metabolic syndrome (MetS) and its complications!
The findings of this study have great implications for the improvement of metabolic syndrome drugs targeting intestinal flora. This paper is also included in the international journal Science Advanced! (1)
▲ "citrus polymethoxyflavone improves metabolic syndrome by regulating intestinal flora and amino acid metabolism" was published in science advanced
conclusion
Through different experiments, we found that pmfe had no toxicity to HL-7702 cell line, and could reduce lipid accumulation through mTOR / P70S6K / SREBP pathway.
In vivo experiments, combined with 16S sequencing analysis and metabonomics analysis, showed that pmfe inhibited the metabolic syndrome in a dose-dependent manner, alleviated the intestinal flora imbalance induced by HFD, and improved the metabolism of BCAAs.
Antibiotic therapy and fecal bacteria transplantation (FMT) experiments further demonstrated that pmfe inhibited diet induced MetS in a gut flora dependent manner. Pmfe can enrich Bacteroides ovalis in intestinal flora, regulate the concentration of circulating amino acids, so as to reduce obesity and metabolic disorder caused by diet. (1)
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In fact, tangerine peel not only plays a role in improving metabolic syndrome, but also has good medicinal value in respiratory system, cardiovascular system, immunity, antioxidation, antibacterial and anti-tumor.
In the novel coronavirus pneumonia control program, Pericarpium Citri is frequently included in its new medicinal value.
In the novel coronavirus pneumonia diagnosis and treatment plan (trial version fourth) released by the National Health Protection Commission and the State Administration of traditional Chinese medicine, the dried orange peel is among the fifth, sixth and seventh edition. 2 - 3.
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Under novel coronavirus pneumonia theory, novel coronavirus pneumonia is the most important guideline in the treatment of new crown pneumonia in Guangdong Province, according to the clinical characteristics of new crown pneumonia and the physical characteristics of South of the Five Ridges. ④ ▲ slide to see next
The new treasure hall lasted ten years
43 research results witness the value of Xinhui tangerine peel
As early as 2007, xinbaotang has begun to join in the research work of tangerine peel. It has successively cooperated with China Pharmaceutical University, Taiwan Nantai University of science and technology, Zhongshan University, Wuyi University, Guangzhou Medical University, Guangzhou University of traditional Chinese medicine, Zhongnan University of finance, politics and law, South China University of science and technology, Guangdong Academy of traditional Chinese medicine, integrated hospital of Chinese and Western medicine of Southern Medical University, southern economic crop research of Chinese Academy of Agricultural Sciences The research center, the agricultural biological gene research center of Guangdong Academy of Agricultural Sciences, and eight universities, two top three hospitals and two scientific research institutions, including Dr. Tokyo University of Japan, Professor of Institute of Biochemistry and molecular biology of Yangming University of Taiwan, President of Asian Lactobacillus Association, and Professor Cai Yingjie, an intestinal expert, have established industrial university research and business cooperation relations. And the scientific research achievements were successfully transformed into Chenpi enzyme. The overall technology of xinbaotang Chenpi enzyme reached the leading level in China through the evaluation of Guangdong Southern food and pharmaceutical industry evaluation center.
At present, the scientific research team of xinbaotang undertakes to preside over three national natural fund projects for the research of tangerine peel, six projects at the provincial level, eight SCI international journal papers, 20 domestic research papers, and six patent applications. The quality standard of tangerine peel medicine drafted by xinbaotang is included in the USP. It has made outstanding achievements in the research of chemical composition and pharmacological activity, the active composition of natural product, extract and quality control of the genuine Chinese medicine.
One
This paper was published in Chromatography A, an authoritative SCI journal, by the cooperation of China Pharmaceutical University and xinbaotang on the chemical composition and metabolism of polymethoxyflavone in Pericarp of Guangdong Province. It was confirmed that polymethoxyflavone (PMFs) in Pericarp of Guangdong Province has the properties of antiviral microorganism, antimutagenic, antiplatelet aggregation, anticancer, anti-inflammatory, protecting gastric mucosa, neuroprotection and preventing cardio cerebral blood Pharmacological activities of vascular diseases. 5.
Two
The paper "polymethoxyflavone and its biological activity in Pericarpium Citri Reticulatae" was successfully published in the SCI authoritative journal "Food Chemistry". Pharmacological research shows that Pericarpium Citri Reticulatae has a variety of biological activities, including anti-inflammatory, anti-oxidation, anti-tumor, anti bacteria and anti atherosclerosis. 6.
Three
Xinbaotang, Guangzhou Medical University and China Pharmaceutical University have completed the research paper "Xinhui Citrus enzyme composition comprehensive determination", and published the research results in the Chinese Core Academic Journal of RCCSE "Chinese Journal of hospital pharmacy". The results showed that Xinhui orange enzyme was rich in total flavonoids, polysaccharides, proteins and amino acids, which had good health and nutritional value. ⑦
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Four
The paper "inhibition of proliferation and induction of apoptosis of CNPC c666-1 cells by chuanchenpi", CO researched by Guangzhou Medical University and xinbaotang, and chaired by Dr. Zheng Guodong, was published in the SCI International Journal Food Science & amp; Nutrition has been published successfully. It has been confirmed that the main effective component of Xinhui tangerine peel, chuanchenpeisu, can significantly inhibit the proliferation and induce apoptosis of c666-1 cells! A kind of
Five
Xinbaotang and Guangzhou Medical University launched the project of simultaneous determination of 7 components in Xinhui orange seeds by HPLC, which was successfully published in Chinese patent medicine, the core journal of science and technology in China. In addition to limonoids, Xinhui Citrus kernel also contains some alkaloids such as synephrine, phenolic acids such as gallic acid and flavonoids. A kind of
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Six
Xinbaotang and Guangzhou Medical University successfully completed the project of comprehensive analysis and determination of chemical composition of Xinhui tangerine peel, and published it in the Chinese Core Academic Journal of RCCSE, Chinese Journal of hospital pharmacy. This study shows that in addition to the volatile oil, Xinhui orange peel mainly contains flavonoids, but also some alkaloids, phenolic acids and limonoids. A kind of
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Seven
In Journal of separation science, an International Journal of SCI, we have successfully published the identification and content determination of the chemical constituents of Citrus kernel (Xinhui Citrus seed) by ultra high performance liquid chromatography tandem mass spectrometry
▲ the paper "identification and content determination of the chemical components of orange kernel (Xinhui orange seed) by ultra high performance liquid chromatography tandem mass spectrometry" was published in Journal of separation science
Xinbaotang and Guangzhou Medical University jointly completed the project "identification and content determination of the chemical components of Citrus kernel (Xinhui Citrus seed) by ultra high performance liquid chromatography tandem mass spectrometry". It was found that Xinhui Citrus kernel identified 35 chemical components, including 21 flavonoid compounds and 14 other compounds. Among them, 21 flavonoids were first reported in Citrus nucleus.
The results showed that the contents of Limonin, hesperidin, chuanchenpi, xinfulin, hesperidin, 3,5,6,7,8,3 ', 4' - heptanoxyflavone and 5-hydroxy-6,7,8,3 ', 4' - pentamethoxyflavone were 11.1666, 0.0404, 0.0092, 0.0255, 0.0087, 0.0010 and 0.0008 mg / g respectively. ?
Eight
In ACS Omega, an International Journal of SCI, the paper "supercritical CO2 fluid extraction combined with ultra high performance liquid chromatography tandem mass spectrometry for the analysis and identification of chemical constituents in Citrus kernel (Xinhui Citrus seed)" was published successfully
The paper "supercritical CO2 fluid extraction combined with ultra high performance liquid chromatography tandem mass spectrometry for the analysis and identification of the chemical components of Citrus kernel (Xinhui Citrus seed)" was successfully published in ACS Omega
The paper "supercritical CO2 fluid extraction combined with ultra high performance liquid chromatography tandem mass spectrometry analysis and identification of the chemical constituents of Citrus kernel (Xinhui Citrus seed)", CO researched by Guangzhou Medical University and xinbaotang, presided over by Dr. Zheng Guodong, was published in the international journal ACS According to omega, there are 28 compounds in Xinhui Citrus kernel, among which esters and flavonoids are the main compounds identified in the extracts. In addition, 2 phenols, 2 aldehydes, 2 triterpenes and 5 other compounds were identified. ?
The skin, meat, dregs, juice and kernel of Xinhui orange are all natural excellent products with rich value. The scientific research achievements of Xinhui orange and Xinhui orange peel are another exploration of xinbaotang in the field of comprehensive utilization of Xinhui orange, which lays a solid scientific research foundation for the future development of new products and the full utilization of Xinhui orange.
Extended reading: Ms. xinbaotang sleep enzyme
Ms. xinbaotang's sleep enzyme is formulated by the disease prevention and treatment center of Guangdong Hospital of traditional Chinese medicine, It is a healthy food focusing on women's deep sleep, which is formed by the cooperation of production, learning and research of eight universities in China, combining the medicine and food of the same origin, such as Xinhui orange peel, ginseng (artificial planting), wolfberry, tuckahoe, ginger, hawthorn, etc., through the technology of nano wall breaking, extraction and biological fermentation! The results showed that it was rich in γ - aminobutyric acid, crude polysaccharide, total flavonoids, polyphenols, lactic acid and other active ingredients, among which γ - aminobutyric acid content was plant enzyme issued by Ministry of industry and information technology of the people's Republic of China（ Edible plant enzyme) industry standard 2500 times, crude polysaccharide 20 times, lactic acid 21.8 times, total flavonoids 26.8 times, orange 21.6 times, balsam pear 12.6 times, banana 9.2 times, onion 7.5 times, grape 7.1 times, strawberry 5.7 times, hawthorn 3.8 times. The overall technology of xinbaotang orange peel enzyme has reached the leading level in China through the evaluation of Guangdong Southern food and medicine industry evaluation center.
Reference
①Su-Ling Zeng , Shang-Zhen Li , Ping-Ting Xiao, et al. Citrus polymethoxyflavones attenuate metabolic syndrome by regulating gut microbiome and amino acid metabolism. Sci. Adv. 2020 January 3.
Novel coronavirus pneumonia diagnosis and treatment plan (trial version sixth)
http://yzs.satcm.gov.cn/zhengcewenjian/2020-02-19/13221.html
3. A novel coronavirus pneumonia diagnosis and treatment plan (trial version 7).
http://bgs.satcm.gov.cn/zhengcewenjian/2020-03-04/13594.html
Novel coronavirus pneumonia guidelines issued by Zhuhai health and Health Bureau on the issue of new prevention of disease in Guangdong Province
http://wsjkj.zhuhai.gov.cn/zwgk/tzgg/content/post_2477717.html
⑤ Zeng suling, Duan Li, Chen Baizhong, Li Ping, Liu Ehu, State Key Laboratory of natural drug active components and efficacy, China Pharmaceutical University, Guangdong xinbaotang Biotechnology Co., Ltd. studies on the chemical composition and metabolism of polymethoxyflavone in Pericarp of Guangchen